Flupirtine is an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. In 2010 the chemically related drug (the difference being that the pyridine group in flupirtine is replaced with a phenyl group) retigabine (INN; ezogabine [USAN]) was approved by the FDA as an anticonvulsant for the treatment of refractory partial-onset seizures in treatment-experienced patients. Retigabine also works by opening the neuronal KCNQ/Kv7 potassium channel, just like flupirtine.

CAS：56995-20-1
中文别名：N-[2-氨基-6-[(4-氟苯基)甲基氨基]吡啶-3-基]氨基甲酸乙酯;氟吡啶;2-氨基-6-[(P-氟苄基)氨基]-3-吡啶氨基甲酸乙酯;
英文别名：Effirma;Flupirtine;
分子式：C15H17FN4O2
分子量：304.319
精确质量：304.134
Psa：89.27
Logp：3.7106

EINECS号：260-503-8

密度：1.35g/cm3
沸点：434.9ºC at 760mmHg
熔点：115 - 116ºC
闪点：216.8ºC
折射率：1.661