Formestane (trade name Lentaron) is a type I, steroidal, selective aromatase inhibitor. It is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced. Formestane is an analogue of androstenedione.

CAS：566-48-3
中文别名：4-雄烯-4-醇-3,17-二酮;福美斯坦;4-羟基雄甾烷-4-烯-3,17-二酮;
英文别名：Lentaron;(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione;B,Aromatase inhibitor;4-Hydroxyandrost-4-ene-3,17-dione;4-Hydroxy-4-androstene-3,17-dione;4-androsten-4-ol-3,17-dione;4-Hydroxyandrostenedione;4-OH-A;Formestane;
分子式：C19H26O3
分子量：302.408
精确质量：302.188
Psa：54.37
Logp：3.9731

UNII：PUB9T8T355

外观与性状：白色粉末
密度：1.19g/cm3
沸点：475.4ºC at 760mmHg
熔点：199-202°C
闪点：255.4ºC
折射率：1.545
储存条件：2-8ºC

RTECS号：BV8152500
安全说明：S53-S36/37/39-S45
WGK Germany：3
危险类别码：R60
危险品标志：T

生产方法
1. 雄甾-4-烯-3,17-二酮(Ⅰ)(1.432g,5mm 1.芳香化酶抑制剂。用于进行性乳腺癌。
用途
1.芳香化酶抑制剂。用于进行性乳腺癌。