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化合物简介
Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors.
基本信息
CAS：546-06-5
中文别名：地麻素;
英文别名：CONESSIN;Con-5-enin-3-amine, N,N-dimethyl-, (3β)-;WRIGHTINE;ROQUESSINE;NERVINE;NERIINE;ROGUESSINE;Conessine,N,N-Dimethyl-con-5-enin-3-amine;5-CONENIN-3BETA-DIMETHYLAMINE;1-Deazaadenosine;
分子式：C24H40N2
分子量：356.588
精确质量：356.319
Psa：6.48
Logp：4.7475
中文别名：地麻素;
英文别名：CONESSIN;Con-5-enin-3-amine, N,N-dimethyl-, (3β)-;WRIGHTINE;ROQUESSINE;NERVINE;NERIINE;ROGUESSINE;Conessine,N,N-Dimethyl-con-5-enin-3-amine;5-CONENIN-3BETA-DIMETHYLAMINE;1-Deazaadenosine;
分子式：C24H40N2
分子量：356.588
精确质量：356.319
Psa：6.48
Logp：4.7475
编号系统
UNII：EZ38J9BBDF
物化性质
密度：1.05g/cm3
沸点：450.4ºC at 760 mmHg
熔点：126-127ºC
闪点：199.6ºC
折射率：1.564
储存条件：Store at RT
沸点：450.4ºC at 760 mmHg
熔点：126-127ºC
闪点：199.6ºC
折射率：1.564
储存条件：Store at RT
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
Predict 1H proton NMR
13C NMR : Predict
1H NMR : Predict
