Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors, and one of the most potent AMPA receptor agonists known. It causes excitotoxicity and is used in neuroscience to selectively destroy neurons in the brain or spinal cord. Quisqualic acid occurs naturally in the seeds of Quisqualis species.[α] 20D = +17 (6M HCl); Research conducted by the USDA Agricultural Research Service, has demonstrated quisqualic acid is also present within the flower petals of zonal geranium (Pelargonium x hortorum) and is responsible for causing rigid paralysis of the Japanese beetle. Quisqualic acid is thought to mimic L-glutamic acid, which is a neurotransmitter in the insect neuromuscular junction and mammalian central nervous system.

CAS：52809-07-1
中文别名：L-使君子氨酸;
英文别名：L-Quisqualic acid,(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoicacid;
分子式：C5H7N3O5
分子量：189.126
精确质量：189.039
Psa：131.32
Logp：-1.7582

MDL号：MFCD00069337

外观与性状：白色粉末
密度：1.679g/cm3
熔点：185-187ºC dec.
折射率：1.571
稳定性：Stable. Incompatible with strong oxidizing agents.
储存条件：2-8ºC

安全说明：S26; S36
危险类别码：R20/21/22
海关编码：2934999090
危险品标志：Xn
危险标志：GHS07
危险性防范说明：P280
危险性描述：H302; H312; H332
信号词：Warning

用途
生化研究,使君子酸受体的兴奋剂,拮抗谷氨酸能竞争中枢神经元的谷氨酸受体。