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化合物简介
Prinaberel (INN, USAN) (developmental code names ERB-041, WAY-202041) is a synthetic, non-steroidal, and highly selective agonist of the ERβ subtype of the estrogen receptor. It is used in scientific research to elucidate the role of the ERβ receptor. Studies have indicated that selective ERβ agonists like prinaberel could be useful in the clinical treatment of a variety of medical conditions including inflammatory bowel disease, rheumatoid arthritis, endometriosis, and sepsis. Accordingly, prinaberel either was or still is under investigation by Wyeth for the treatment of some of these conditions.
基本信息
CAS:524684-52-4
中文别名:2-(3-氟-4-羟基苯基)-7-乙烯基-1,3-苯并恶唑-5-醇;
英文别名:2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol;SDZ 205-557 hydrochloride;Prinaberel;UNII-A9C8MNF7CA;BIDD:ER0139;1x7b;ERB 041;
分子式:C15H10FNO3
分子量:271.243
精确质量:271.064
Psa:66.49
Logp:3.6881
中文别名:2-(3-氟-4-羟基苯基)-7-乙烯基-1,3-苯并恶唑-5-醇;
英文别名:2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol;SDZ 205-557 hydrochloride;Prinaberel;UNII-A9C8MNF7CA;BIDD:ER0139;1x7b;ERB 041;
分子式:C15H10FNO3
分子量:271.243
精确质量:271.064
Psa:66.49
Logp:3.6881
编号系统
UNII:A9C8MNF7CA
物化性质
密度:1.413
沸点:379.9ºC at 760 mmHg
熔点:250-252ºC
闪点:183.6ºC
沸点:379.9ºC at 760 mmHg
熔点:250-252ºC
闪点:183.6ºC
安全信息
危险标志:GHS07
危险性防范说明:P305 + P351 + P338
信号词:Warning
危险性描述:H302; H319
危险性防范说明:P305 + P351 + P338
信号词:Warning
危险性描述:H302; H319
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
