化学科研者一站式服务平台
化合物简介
Tipepidine (INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.
基本信息
CAS:5169-78-8
中文别名:
英文别名:3-(di-thiophen-2-yl-methylene)-1-methyl-piperidine;Piperidine, 3-(di-2-thienylmethylene)-1-methyl-;Tipepidine;(1-Methyl-3-piperidylidene)di(2-thienyl)methane;Tipedine;3-(Di-[2]thienyl-methylen)-1-methyl-piperidin;Tipepidina [INN-Spanish];Tipepidinum [INN-Latin];3-(di-[2]thienyl-methylene)-1-methyl-piperidine;(1-Methyl-3-piperidyliden)di-2-thienylmethan-embonat;Asverin;AT 327;CR/662;Tipepidine [INN:DCF];Bitiodin;
分子式:C15H17NS2
分子量:275.432
精确质量:275.08
Psa:59.72
Logp:4.275
中文别名:
英文别名:3-(di-thiophen-2-yl-methylene)-1-methyl-piperidine;Piperidine, 3-(di-2-thienylmethylene)-1-methyl-;Tipepidine;(1-Methyl-3-piperidylidene)di(2-thienyl)methane;Tipedine;3-(Di-[2]thienyl-methylen)-1-methyl-piperidin;Tipepidina [INN-Spanish];Tipepidinum [INN-Latin];3-(di-[2]thienyl-methylene)-1-methyl-piperidine;(1-Methyl-3-piperidyliden)di-2-thienylmethan-embonat;Asverin;AT 327;CR/662;Tipepidine [INN:DCF];Bitiodin;
分子式:C15H17NS2
分子量:275.432
精确质量:275.08
Psa:59.72
Logp:4.275
编号系统
UNII:2260ZP67IT
物化性质
储存条件:库房通风低温干燥,与氧化剂、酸类分开存放
安全信息
海关编码:2934999090
生产方法及用途
合成路线
-
参考文献
Okumura et al. Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1958 , vol. 3, # 2 p. 30,32 Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1959 , p. 10214
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict




