Allopregnanolone (ALLO), also known as 3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), is an endogenous inhibitory pregnane neurosteroid. It is synthesized from progesterone, and is a potent positive allosteric modulator of the action of gamma-amininobutyric acid (GABA) at GABAA receptor. Allopregnanolone has effects similar to those of other positive allosteric modulators of the GABA action at GABAA receptor such as the benzodiazepines, including anxiolytic, sedative, and anticonvulsant activity.

CAS：516-54-1
中文别名：3Α-孕烷醇酮;5ALPHA-孕甾-3ALPHA-醇-20-酮;5α-Pregnan-3α-ol-20-one;
英文别名：(3α)-Allopregnanolone;3alpha-hydroxy-5alpha-pregnan-20-one;Pregnan-20-one, 3-hydroxy-, (3α,5α)-;ALLOPREGNAN-3ALPHA-OL-20-ONE;
分子式：C21H34O2
分子量：318.493
精确质量：318.256
Psa：37.3
Logp：4.5952

UNII：S39XZ5QV8Y

密度：1.053g/cm3
沸点：431.2ºC at 760mmHg
闪点：183.9ºC
折射率：1.524
储存条件：Store at RT

安全说明：S22; S24/25