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化合物简介
Chlormethine (INN, BAN), mechlorethamine (widely used in the US, not the USAN, however) also known as mustine and HN2 and in former USSR known as Embichin is a nitrogen mustard sold under the brand name Mustargen. It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication. It binds to the N7 nitrogen on the DNA base guanine. As the chemical is a blister agent, its use is strongly restricted within the Chemical Weapons Convention where it is classified as a Schedule 1 substance.
基本信息
CAS:51-75-2
中文别名:双(2-氯乙基)甲胺;
英文别名:Chlormethine;Mustine;N,N-bis(2-chloroethyl)methylamine;Chlorethazine;Nitrogranulogen;N-methyl-bis-(2-chloroethyl)amine;Bis(2-chloroethyl)methylamine;Caryolysine;Embichin;Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-;methyl-bis-(2-chloro-ethyl)-amine;2-chloro-N-(2-chloroethyl)-N-methylethanamine;Nitrogen mustard;Mustargen;
分子式:C5H12Cl3N
分子量:192.514
精确质量:191.004
Psa:3.24
Logp:2.1978
中文别名:双(2-氯乙基)甲胺;
英文别名:Chlormethine;Mustine;N,N-bis(2-chloroethyl)methylamine;Chlorethazine;Nitrogranulogen;N-methyl-bis-(2-chloroethyl)amine;Bis(2-chloroethyl)methylamine;Caryolysine;Embichin;Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-;methyl-bis-(2-chloro-ethyl)-amine;2-chloro-N-(2-chloroethyl)-N-methylethanamine;Nitrogen mustard;Mustargen;
分子式:C5H12Cl3N
分子量:192.514
精确质量:191.004
Psa:3.24
Logp:2.1978
编号系统
UNII:50D9XSG0VR
物化性质
外观与性状:非固定的液体
密度:1.106g/cm3
沸点:110.3ºC at 760mmHg
熔点:-60ºC
闪点:20.5ºC
折射率:1.455
储存条件:库房通风低温干燥,与食品原料分开存放
蒸汽密度:3.35 (vs air)
蒸汽压:18 mm Hg ( 20 °C)
密度:1.106g/cm3
沸点:110.3ºC at 760mmHg
熔点:-60ºC
闪点:20.5ºC
折射率:1.455
储存条件:库房通风低温干燥,与食品原料分开存放
蒸汽密度:3.35 (vs air)
蒸汽压:18 mm Hg ( 20 °C)
安全信息
RTECS号:UC6650000
安全说明:S16; S26; S36/37/39; S45
危险类别码:R11; R20/22; R24; R34
WGK Germany:3
危险品运输编码:2810
海关编码:2921194000
危险类别:6.1(a)
包装等级:II
危险品标志:F; T
安全说明:S16; S26; S36/37/39; S45
危险类别码:R11; R20/22; R24; R34
WGK Germany:3
危险品运输编码:2810
海关编码:2921194000
危险类别:6.1(a)
包装等级:II
危险品标志:F; T
生产方法及用途
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13C NMR : Predict

1H NMR : Predict
