TPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.

CAS：507475-17-4
中文别名：5-(4-氟苯基)-2-脲基噻吩-3-甲酰胺;
英文别名：IKK-2 Inhibitor IV;2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide;GW683965 GW683965A [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide;3qfv;
分子式：C12H10FN3O2S
分子量：279.29
精确质量：279.048
Psa：126.45
Logp：3.6173

密度：1.491g/cm3
沸点：442.576ºC at 760 mmHg
闪点：221.462ºC
折射率：1.686
储存条件：2-8ºC

安全说明：S26
危险类别码：R22; R36
危险品标志：Xn
危险性描述：H302; H319
信号词：Warning
危险标志：GHS07
危险性防范说明：P301 + P312 + P330; P305 + P351 + P338