Desipramine (also known as desmethylimipramine) is a tricyclic antidepressant (TCA). It inhibits the reuptake of norepinephrine and to a minor extent serotonin. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine. It is sold under the brand names Norpramin, and Pertofrane.

CAS：50-47-5
中文别名：3-(10,11-二氢-5H-二苯并[B,F]氮杂卓-5-基)-N-甲基丙-1-胺;去甲丙咪嗪;
英文别名：Desipramin;Desipramine;Demethylimipramine;10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz(b,f)azepin;Norimipramine;Monodemethylimipramine;3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine;3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine;5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine;Desimipramine;[3H]-Desipramine;[14C]-Desipramine;Desmethylimipramine;Pertofrane;Dimethylimipramine;Dezipramine;
分子式：C18H22N2
分子量：266.381
精确质量：266.178
Psa：15.27
Logp：3.9887

UNII：TG537D343B

密度：1.047 g/cm3
沸点：407.4ºC at 760 mmHg
闪点：160.5ºC

安全说明：S36
危险类别码：R20/21/22
海关编码：2933990090
危险品标志：Xn

生产方法
由二苯并氮杂卓为原料制得。 为抗抑郁药，有阻滞草胺类神经介质如去甲肾上腺素或5-羟色胺回收的作用。用于治疗各种抑郁症。
用途
为抗抑郁药，有阻滞草胺类神经介质如去甲肾上腺素或5-羟色胺回收的作用。用于治疗各种抑郁症。