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6-[4-[(4-乙基-1-哌嗪)甲基]苯基]-N-[(1R)-1-苯基乙基]-7H-吡咯并[2,3-d]嘧啶-4-胺
6-(4-((4-ethyl-1-piperazinyl)methyl)phenyl)-N-((1R)-1-phenylethyl)-1H-Pyrrolo(2,3-D)pyrimidin-4-amine
化合物简介
A novel dual receptor tyrosine kinase inhibitor of the EGF and the VEGF receptor, for treatment of human HCC cell lines and in a s.c. xenograft model.
基本信息
CAS：497839-62-0
中文别名：
英文别名：Nifurpirinol [USAN:INN];Furanace;Nifurpirinolum [INN-Latin];Furpirinol;[6-[4-(4-ethyl-piperazine-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrinidinpyrimidin-4-yl]-((R)-1-phenyl-ethyl)-amine;AEE788 (NVP-AEE788);[6-[4-[(4-ethylpiperazine-1-yl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidine-4-yl]-((R)-1-phenylethyl)amine;Furpyrinol;Nifurpirinol;{6-[2-(5-nitro-furan-2-yl)-vinyl]-pyridin-2-yl}-methanol;{6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2.3-d]-pyrimidin-4-yl}-((R)-1-phenyl-ethyl)-amine;(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;Furanace-10;
分子式：C27H32N6
分子量：440.583
精确质量：440.269
Psa：63.31
Logp：4.2332
中文别名：
英文别名：Nifurpirinol [USAN:INN];Furanace;Nifurpirinolum [INN-Latin];Furpirinol;[6-[4-(4-ethyl-piperazine-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrinidinpyrimidin-4-yl]-((R)-1-phenyl-ethyl)-amine;AEE788 (NVP-AEE788);[6-[4-[(4-ethylpiperazine-1-yl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidine-4-yl]-((R)-1-phenylethyl)amine;Furpyrinol;Nifurpirinol;{6-[2-(5-nitro-furan-2-yl)-vinyl]-pyridin-2-yl}-methanol;{6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2.3-d]-pyrimidin-4-yl}-((R)-1-phenyl-ethyl)-amine;(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;Furanace-10;
分子式：C27H32N6
分子量：440.583
精确质量：440.269
Psa：63.31
Logp：4.2332
编号系统
UNII：F9JLR95I3I
物化性质
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
