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  • 7,8-二羟基黄酮

    7,8-DIHYDROXYFLAVONE

化合物简介

7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF). 7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier.

基本信息

CAS:38183-03-8
中文别名
英文别名:7,8-dihydroxy-2-phenylchromen-4-one;7,8-Dihydroxy-2-phenyl-4H-chromen-4-one;7,8-Dihydroxyflavone;7,8-Dihydroxyflavone Hydrate;
分子式:C15H10O4
分子量:254.237
精确质量:254.058
Psa:70.67
Logp:2.8712

编号系统

MDL号:MFCD00006836

物化性质

密度:1.443g/cm3
沸点:494.4ºC at 760 mmHg
熔点:243-246°C
闪点:193.5ºC
折射率:1.698

安全信息

RTECS号:DJ3004000
安全说明:S24/25
海关编码:2914400090
信号词:Warning
危险性描述:H302
危险标志:GHS07

生产方法及用途

合成路线

上游原料

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图谱

13C NMR : Predict


1H NMR : Predict


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