Tenofovir alafenamide (INN/USAN, formerly GS-7340) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir. It was developed by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil, TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent.

CAS：379270-37-8
中文别名：GS7340游离碱;
英文别名：GS-7340;Sp-Tenofovir-phosphonamidate,phenyl,L-alanine isopropyl ester;TENOFOVIR ALAFENAMIDE;propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate;Tenofovir alafenamide free base;
分子式：C21H29N6O5P
分子量：476.466
精确质量：476.194
Psa：153.29
Logp：3.945

UNII：EL9943AG5J

密度：1.39±0.1g/cm3
沸点：640.4±65.0°Cat760mmHg
闪点：341.1±34.3°C
外观性状：白色粉末
蒸汽压：0.0±1.9mmHgat25°C
折射率：1.630
储存条件：室温，干燥
水溶解性：Practicallyinsoluble(0.04g/L)(25ºC)