Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion. It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism. With oral bupropion treatment, hydroxybupropion is present in plasma at area under the curve concentrations that are as many as 16–20 times greater than those of bupropion itself, demonstrating extensive conversion of bupropion into hydroxybupropion in humans. As such, hydroxybupropion is likely to play a very important role in the effects of oral bupropion, which could accurately be thought of as functioning largely as a prodrug to hydroxybupropion.

CAS：357399-43-0
中文别名：
英文别名：2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol;
分子式：C13H18ClNO2
分子量：255.741
精确质量：255.103
Psa：41.49
Logp：2.6008

密度：1.144 g/cm3
沸点：386.574ºC at 760 mmHg
闪点：187.594ºC

海关编码：2934999090