Hypusine is an unusual amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known protein containing hypusine is eukaryotic translation initiation factor 5A (eIF5A) and a similar protein found in archaebacteria. In humans, two isoforms of eIF-5A have been described: eIF5A-1 and eIF5A-2. They are encoded by two different genes EIF5A and EIF5A2. The protein is involved in protein biosynthesis and promotes the formation of the first peptide bond. The region surrounding the hypusine residue is highly conserved and is essential to the function of eIF5A. Thus, hypusine and eIF-5A appear to be vital for the viability and proliferation of eukaryotic cells.

CAS：34994-11-1
中文别名：
英文别名：Hypusine;2-amino-6-[(4-amino-2-hydroxybutyl)amino]hexanoic acid;
分子式：C10H23N3O3
分子量：233.308
精确质量：233.174
Psa：121.6
Logp：0.6594

密度：1.151g/cm3
沸点：465.2ºC at 760 mmHg
闪点：235.1ºC
折射率：1.524

海关编码：2922509090