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化合物简介
Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages.
基本信息
CAS:302-79-4
中文别名:维他命A酸;视黄酸;维甲酸;维A酸;3,7-二甲基-9-(2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸;
英文别名:(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;eudyna;all-trans retinoic acid;effederm;all-trans-Retinoic Acid;13-trans-Retinoic acid;13-cis-retinoic acid;aknoten;all-trans-vitamin A acid;retin-a;aberel;all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid;Atragen;all-trans tretinoin;Vitamin A Acid;[3H]-Retinoic Acid;tretinm;(all-e);ATRA;Retinoic acid;Tretinoin;
分子式:C20H28O2
分子量:300.435
精确质量:300.209
Psa:37.3
Logp:5.6026
中文别名:维他命A酸;视黄酸;维甲酸;维A酸;3,7-二甲基-9-(2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸;
英文别名:(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;eudyna;all-trans retinoic acid;effederm;all-trans-Retinoic Acid;13-trans-Retinoic acid;13-cis-retinoic acid;aknoten;all-trans-vitamin A acid;retin-a;aberel;all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid;Atragen;all-trans tretinoin;Vitamin A Acid;[3H]-Retinoic Acid;tretinm;(all-e);ATRA;Retinoic acid;Tretinoin;
分子式:C20H28O2
分子量:300.435
精确质量:300.209
Psa:37.3
Logp:5.6026
编号系统
MDL号:MFCD00001551
物化性质
外观与性状:黄色-橙色粉末
密度:1.011 g/cm3
沸点:462.8ºC at 760 mmHg
熔点:179-184ºC
闪点:350.6ºC
密度:1.011 g/cm3
沸点:462.8ºC at 760 mmHg
熔点:179-184ºC
闪点:350.6ºC
安全信息
安全说明:S36/37-S45
危险类别码:R22; R38; R63
海关编码:2916209090
危险品标志:Xn
危险标志:GHS07
危险性描述:H302
危险性防范说明:P301 + P312 + P330
信号词:Warning
危险类别码:R22; R38; R63
海关编码:2916209090
危险品标志:Xn
危险标志:GHS07
危险性描述:H302
危险性防范说明:P301 + P312 + P330
信号词:Warning
生产方法及用途
用途
本品系体内维生素A的代谢中间产物,主要影响骨的生长和促进上皮细胞增生、分化、角质溶解等代谢作用。用于异常型鱼鳞和异常型银屑病。
本品系体内维生素A的代谢中间产物,主要影响骨的生长和促进上皮细胞增生、分化、角质溶解等代谢作用。用于异常型鱼鳞和异常型银屑病。
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict

IR : KBr disc
