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化合物简介

Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation sulfonylureas are both more potent and have shorter half-lives than the first-generation sulfonylureas.

基本信息

CAS:29094-61-9
中文别名:格列甲嗪;
英文别名:Ozidia;exylurea;N-[4-(3-Cyclohexylureidosulfonyl)phenethyl]-5-methyl-2-pyrazinecarboxamide;1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea;Digrin;k4024;tk1320;Glipizide;Melizide;Aldiab;Glipid;Glidiab;Glican;
分子式:C21H27N5O4S
分子量:445.535
精确质量:445.178
Psa:138.53
Logp:4.3316

编号系统

MDL号:MFCD00072159

物化性质

外观与性状:白色或灰白色结晶粉末
密度:1.34 g/cm3
熔点:208-209°C
折射率:1.597
储存条件:Store in a tightly closed container. Store in a dry area. Store at around 20ºC.

安全信息

RTECS号:YS7640000
安全说明:S24/25
危险类别码:R21
WGK Germany:3
海关编码:2935009090
危险品标志:Xi; Xn

生产方法及用途

用途
为非胰岛素依赖型(Ⅱ)型糖尿病之降糖良药,本品主要用于单用饮食控制治疗未能达到良好效果的轻、中度非胰岛素依赖型病人。

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图谱

Predict 1H proton NMR


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