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化合物简介
Netupitant is an antiemitic drug. In the United States, the combination drug netupitant/palonosetron (trade name Akynzeo) is approved by the Food and Drug Administration for prevention of acute and delayed chemotherapy-induced nausea and vomiting, including highly emetogenic chemotherapy such as with cisplatin. In Europe, it is approved by the European Medicines Agency for the same indication.
基本信息
CAS:290297-26-6
中文别名:
英文别名:Netupitant;2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide;UNII-7732P08TIR;Netupitan;
分子式:C30H32F6N4O
分子量:578.592
精确质量:578.248
Psa:39.68
Logp:6.7899
中文别名:
英文别名:Netupitant;2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide;UNII-7732P08TIR;Netupitan;
分子式:C30H32F6N4O
分子量:578.592
精确质量:578.248
Psa:39.68
Logp:6.7899
编号系统
MDL号:MFCD25976831
物化性质
密度:1.255
沸点:597.4ºC at 760 mmHg
闪点:315.1ºC
折射率:1.539
蒸汽压:3.09E-14mmHg at 25°C
沸点:597.4ºC at 760 mmHg
闪点:315.1ºC
折射率:1.539
蒸汽压:3.09E-14mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict

13C NMR : Predict
