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19-去甲-17a-孕甾-1,3,5(10)-三烯-20-炔-3,17-二醇 3-(2-丙烷磺酸酯)
[(8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] propane-2-sulfonate
化合物简介
Ethinyl estradiol sulfonate (EES) (brand name Turisteron), also known as ethinyl estradiol isopropylsulfonate or ethinyl estradiol propanesulfate, as well as 17α-ethinyl-3-isopropylsulfonyloxyestradiol, is a synthetic, steroidal estrogen that is marketed in Germany. It is an ester of ethinyl estradiol, and acts as a long-acting (half-life of six days), orally active depot form of the drug. EES is used in the treatment of advanced breast and prostate cancers. The drug is very potent (used clinically at a dosage of 1–2 mg weekly via intramuscular injection) and a powerful antigonadotropin, capable of suppressing circulating testosterone concentrations to levels comparable to those seen with castration (less than 1–3% of initial values). As such, EES is a strong functional antiandrogen.
基本信息
CAS:28913-23-7
中文别名:
英文别名:Ethinylestradiol propanesulfonate;(17|A)-17-ethynyl-17-hydroxyestra-1,3,5(10)-trien-3-yl propane-2-sulfonate;Ethinyl estradiol isopropylsulfonate;Turisteron;Turisteron (TN);
分子式:C23H30O4S
分子量:402.547
精确质量:402.186
Psa:71.98
Logp:5.1048
中文别名:
英文别名:Ethinylestradiol propanesulfonate;(17|A)-17-ethynyl-17-hydroxyestra-1,3,5(10)-trien-3-yl propane-2-sulfonate;Ethinyl estradiol isopropylsulfonate;Turisteron;Turisteron (TN);
分子式:C23H30O4S
分子量:402.547
精确质量:402.186
Psa:71.98
Logp:5.1048
编号系统
物化性质
蒸汽压:1.51E-12mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict

13C NMR : Predict
