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化合物简介

Nicergoline (INN, marketed under the trade name Sermion) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.

基本信息

CAS:27848-84-6
中文别名:[(8R,10S)-10-甲氧基-1,6-地甲基麦角林-8-基]甲基-5-溴吡啶-3-羧酸酯;5-溴吡啶-3-羧酸-[(8R,10S)-10-甲氧基-1,6-二甲基麦角林-8-基]甲酯;麦角溴烟酯;
英文别名:Sermion;Memoq;Cergodum;mne;fi6714;nargoline;ergoline-8-methanol 10-methoxy-1,6-dimethyl-,8-(5-bromo-3-pyridinecarboxylate);Ergobel;[(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-Bromopyridine-3-carboxylate;5-bromo-nicotinic acid 10-methoxy-1,6-dimethyl-ergolin-8-ylmethyl ester;nigergoline;Dilasenil;5-Bromopyridine-3-carboxylic Acid [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl Ester;TA 079;Ergotop;
分子式:C24H26BrN3O3
分子量:484.386
精确质量:483.116
Psa:56.59
Logp:3.8488

编号系统

UNII:JCV8365FWN

物化性质

密度:1.47 g/cm3
沸点:594.4ºC at 760 mmHg
闪点:313.3ºC
稳定性:Stable at normal temperatures and pressures.
储存条件:2-8ºC
蒸汽压:0mmHg at 25°C

安全信息

安全说明:S36
危险类别码:R22
危险品运输编码:UN 1544
危险类别:6.1(b)
包装等级:III
危险品标志:Xn

生产方法及用途

合成路线

上游原料

下游产品

图谱

Predict 1H proton NMR


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