Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. Due to its extremely long-lasting effects, it is often prescribed to be taken orally as tablets only once a week (q 7 days). The once-weekly dose is usually 10–60mg.

CAS：26864-56-2
中文别名：羟丙基纤维素;1-[4,4-双(4-氟苯基)丁基]-4-[4-氯-3-(三氟甲基)苯基]-4-哌啶醇;1-[4,4-二(4-氟苯基)丁基]-4-[4-氯-3-(三氟甲基)苯基]-4-羟基哌啶;
英文别名：McN-JR-16,341;TLP-607;1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol,R16341;EINECS 248-074-5;1-(4,4-Bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol;1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol;[3H]-Penfluridol;1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol R16341;Semap;Penfluridol;PENFLURIDOL;
分子式：C28H27ClF5NO
分子量：523.965
精确质量：523.17
Psa：23.47
Logp：7.4706

UNII：25TLU22Q8H

外观与性状：灰白色至白色结晶粉末
密度：1.29 g/cm3
沸点：587.7ºC at 760 mmHg
熔点：105-107ºC
闪点：309.2ºC
折射率：1.552
稳定性：Stable at normal temperatures and pressures.
储存条件：2-8ºC
蒸汽压：1.17E-14mmHg at 25°C

RTECS号：TN6957000
安全说明：S45
WGK Germany：3
危险类别码：R25
海关编码：2942000000
危险品运输编码：UN 2811
危险类别：6.1
危险品标志：T
危险性防范说明：P301 + P310
危险标志：GHS06
危险性描述：H301
信号词：Danger

用途
适用于治疗各种类型精神病