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化合物简介

Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor, i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. This is a mechanism of action shared by some recreational drugs like cocaine and the medication Tametraline (see DRI). Research showed that the (S) isomer is responsible for activity.

基本信息

CAS:24526-64-5
中文别名:苯异喹胺;2-甲基-4-苯基-8-氨基-1,2,3,4-四氢异喹啉;
英文别名:2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;Nomifenison;1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin;8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline;linamiphen;Nomifensine Maleate;8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl;8-amino-4-phenyl-2-methyl-1,2,3,4-tetrahydro-isoquinoline;Nomifensine;8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline;Nomifensin;1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin;1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine;
分子式:C16H18N2
分子量:238.328
精确质量:238.147
Psa:29.26
Logp:3.3652

编号系统

物化性质

密度:1.114g/cm3
沸点:378.4ºC at 760mmHg
闪点:164ºC
折射率:1.622
蒸汽压:6.28E-06mmHg at 25°C

安全信息

危险类别码:R22; R36/37/38
危险品运输编码:UN 3249
海关编码:2933499090
危险类别:6.1(b)
包装等级:III
危险品标志:Xn

生产方法及用途

合成路线

上游原料

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图谱

13C NMR : Predict


1H NMR : Predict


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