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化合物简介
Bufexamac is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac. It was withdrawn in Europe because of allergic reactions.
基本信息
CAS:2438-72-4
中文别名:2-(4-丁氧苯基)醋羟胺酸;4-丁氧基-N-羟基苯乙酰胺;对丁氧苯乙酰氧肟酸;
英文别名:2-(4-butoxyphenyl)-N-hydroxyacetamide;Bufexamaco;Flogicid;2-(4-Butoxyphenyl)acetohydroxamic Acid;Bufexamacum;Feximac;Bufexamic acid;4-butoxy-N-hydroxybenzeneacetamide;2-(4-Butoxyphenyl)-N-hydroxyacetamide;Droxaryl;2-(4-butoxyphenyl)acetohydroxamic acid;Benzeneacetamide, 4-butoxy-N-hydroxy-;2-(4-butoxyphenyl)acethydroxamic acid;Malipuran;Parfenac;Bufexamac;2-(p-Butoxyphenyl)acetohydroxamic acid;
分子式:C12H17NO3
分子量:223.268
精确质量:223.121
Psa:58.56
Logp:2.3043
中文别名:2-(4-丁氧苯基)醋羟胺酸;4-丁氧基-N-羟基苯乙酰胺;对丁氧苯乙酰氧肟酸;
英文别名:2-(4-butoxyphenyl)-N-hydroxyacetamide;Bufexamaco;Flogicid;2-(4-Butoxyphenyl)acetohydroxamic Acid;Bufexamacum;Feximac;Bufexamic acid;4-butoxy-N-hydroxybenzeneacetamide;2-(4-Butoxyphenyl)-N-hydroxyacetamide;Droxaryl;2-(4-butoxyphenyl)acetohydroxamic acid;Benzeneacetamide, 4-butoxy-N-hydroxy-;2-(4-butoxyphenyl)acethydroxamic acid;Malipuran;Parfenac;Bufexamac;2-(p-Butoxyphenyl)acetohydroxamic acid;
分子式:C12H17NO3
分子量:223.268
精确质量:223.121
Psa:58.56
Logp:2.3043
编号系统
MDL号:MFCD00078936
物化性质
密度:1.12g/cm3
熔点:161 - 162ºC
折射率:1.53
稳定性:Stable at normal temperatures and pressures.
储存条件:库房通风低温干燥
熔点:161 - 162ºC
折射率:1.53
稳定性:Stable at normal temperatures and pressures.
储存条件:库房通风低温干燥
安全信息
海关编码:2924299090
生产方法及用途
用途
非甾体消炎镇痛药的中间体.适用于急慢性湿疹、神经性皮炎、接触性皮炎、过敏性皮炎、指掌角化症等皮肤病的治疗。
非甾体消炎镇痛药的中间体.适用于急慢性湿疹、神经性皮炎、接触性皮炎、过敏性皮炎、指掌角化症等皮肤病的治疗。
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
