Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2-3% of apamin. Apamin selectively blocks SK channels, a type of Ca2+-activated K+ channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine1, lysine4, arginine13, arginine14 and histidine18. These amino acids are involved in the binding of apamin to the Ca2+-activated K+ channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the afterhyperpolarizations occurring immediately following an action potential.

CAS：24345-16-2
中文别名：蜂毒明肽;CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2(DISULFIDE BRIDGE:CYS1-CYS11,CYS3-CYS15);
英文别名：apamine;CNCKAPETALCARRCQQH-NH2;M.W. 2027.34 C79H131N31O24S4;APAMIN,BEE VENOM;APAMIN FROM BEE VENOM;APAMIN FROM HONEY BEE VENOM;
分子式：C79H131N31O24S4
分子量：2027.34
精确质量：2025.89
Psa：1021.52
Logp：-0.3154

MDL号：MFCD00167944
PubChem号：24890526
EINECS号：246-182-7
RTECS号：CD6899900

折射率：1.724
储存条件：库房通风低温干燥,与食品原料分开存放

RTECS号：CD6899900
安全说明：S22-S24/25
WGK Germany：3
危险品运输编码：UN 2811
危险类别：6.1(b)
包装等级：III