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化合物简介
Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro, Dayrun, Duraprox) is a non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. It is available in 600mg tablets. Normal adult dosage is 1200mg daily, not to exceed 1800mg per day. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.
基本信息
CAS:21256-18-8
中文别名:4,5-二苯基-2-噁唑丙酸;贝美格;恶丙嗪;3-(4,5-二苯基-1,3-恶唑-2-基)丙酸;
英文别名:4,5-Diphenyl-2-oxazolepropanoic acid Daypro;Alvo;4,5-Diphenyl-2-oxazolepropionic Acid;OXAPROSIN;Dxaprozin;4,5-diphenyloxazole-2-propanoic acid;DAYPRO;Duraprost;3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid;Oxapro;4,5-Diphenyl-2-oxazolepropanoic acid,Daypro;Oxaprozin;Actirin;3-(4,5-Diphenyloxazol-2-yl)propanoic acid;Durapro;
分子式:C18H15NO3
分子量:293.317
精确质量:293.105
Psa:63.33
Logp:4.0258
中文别名:4,5-二苯基-2-噁唑丙酸;贝美格;恶丙嗪;3-(4,5-二苯基-1,3-恶唑-2-基)丙酸;
英文别名:4,5-Diphenyl-2-oxazolepropanoic acid Daypro;Alvo;4,5-Diphenyl-2-oxazolepropionic Acid;OXAPROSIN;Dxaprozin;4,5-diphenyloxazole-2-propanoic acid;DAYPRO;Duraprost;3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid;Oxapro;4,5-Diphenyl-2-oxazolepropanoic acid,Daypro;Oxaprozin;Actirin;3-(4,5-Diphenyloxazol-2-yl)propanoic acid;Durapro;
分子式:C18H15NO3
分子量:293.317
精确质量:293.105
Psa:63.33
Logp:4.0258
编号系统
MDL号:MFCD00215977
物化性质
外观与性状:固体
密度:1.222 g/cm3
沸点:467ºC at 760 mmHg
熔点:154ºC
闪点:236.2ºC
折射率:1.595
稳定性:Stable at normal temperatures and pressures.
储存条件:Keep tightly closed.
蒸汽压:1.6E-09mmHg at 25°C
密度:1.222 g/cm3
沸点:467ºC at 760 mmHg
熔点:154ºC
闪点:236.2ºC
折射率:1.595
稳定性:Stable at normal temperatures and pressures.
储存条件:Keep tightly closed.
蒸汽压:1.6E-09mmHg at 25°C
安全信息
RTECS号:RP6990000
安全说明:S24/25; S36/37/39; S36; S26
危险类别码:R20/21/22
WGK Germany:3
海关编码:2934999090
危险品标志:Xn; Xi
安全说明:S24/25; S36/37/39; S36; S26
危险类别码:R20/21/22
WGK Germany:3
海关编码:2934999090
危险品标志:Xn; Xi
生产方法及用途
用途
用于风湿性关节炎、类风湿性关节炎、骨关节炎、强直性脊椎炎、颈肩腕综合征、肩周炎、痛风及外伤和手术后的消炎镇痛。
用于风湿性关节炎、类风湿性关节炎、骨关节炎、强直性脊椎炎、颈肩腕综合征、肩周炎、痛风及外伤和手术后的消炎镇痛。
合成路线
上游原料
下游产品
图谱
Predict 1H proton NMR

13C NMR : Predict

1H NMR : Predict
