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4-[(1E,3S,5Z,8R/S,10S)-3,11-二-{[叔-丁基(二甲基)硅烷基]氧基}-2,6,10-三甲基-十一碳-1,5-二烯基]-2-甲基-1,3-噻唑
(2S,6Z,9S,10E)-1,9-Bis[(1,1-dimethylethyl)dimethylsilyloxy]-11-(2-methylthiazol-4-yl)-2,6,10-trimethyl-undeca-6,10-diene
化合物简介
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
基本信息
CAS：210690-85-0
中文别名：
英文别名：(+)-4-[(1E,3S,5Z,10S)-3,11-bis{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethylundeca-1,5-dienyl]-2-methyl-1,3-thiazole;4-[(1E,5Z)-(3S,10S)-3,11-bis-(tert-butyldimethylsilanyloxy)-2,6,10-trimethylundeca-1,5-dienyl]-2-methylthiazole;4-[(1E,3S,5Z,10S)-3,11-Di-(tert-butyldimethylsilyloxy)-2,6,10-trimethyl-1,5-undecadienyl]-2-methyl-1,3-thiazole;(6S,10S,2Z,6E)-3,11-di(tert-butyldimethylsilyloxy)-1-(2-methylthiazol-4-yl)-2,6,10-trimethyl-undeca-1,5-diene;
分子式：C30H57NO2SSi2
分子量：552.015
精确质量：551.365
Psa：59.59
Logp：10.4098
中文别名：
英文别名：(+)-4-[(1E,3S,5Z,10S)-3,11-bis{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethylundeca-1,5-dienyl]-2-methyl-1,3-thiazole;4-[(1E,5Z)-(3S,10S)-3,11-bis-(tert-butyldimethylsilanyloxy)-2,6,10-trimethylundeca-1,5-dienyl]-2-methylthiazole;4-[(1E,3S,5Z,10S)-3,11-Di-(tert-butyldimethylsilyloxy)-2,6,10-trimethyl-1,5-undecadienyl]-2-methyl-1,3-thiazole;(6S,10S,2Z,6E)-3,11-di(tert-butyldimethylsilyloxy)-1-(2-methylthiazol-4-yl)-2,6,10-trimethyl-undeca-1,5-diene;
分子式：C30H57NO2SSi2
分子量：552.015
精确质量：551.365
Psa：59.59
Logp：10.4098
