Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).

CAS：208110-64-9
中文别名：1-(3-氯-4-氟苯甲酰基)-4-氟-N-[(5-甲基-2-吡啶基)甲基]-4-哌啶甲胺;
英文别名：UNII-RAT9OHA1YH;Befiradol;
分子式：C20H22ClF2N3O
分子量：393.858
精确质量：393.142
Psa：45.23
Logp：4.2454

UNII：RAT9OHA1YH

密度：1.3