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  • 沙芬酰胺甲磺酸盐

    Safinamide mesylate salt

化合物简介

Safinamide (INN; brand name Xadago, former developmental code name EMD-1195686) is a drug indicated for the treatment of Parkinson's disease with multiple methods of action. In 2007, a Phase III clinical trial was started. It was scheduled to run until 2011. The compound was originally discovered at Farmitalia-Carlo Erba, first published in 1998 and developed by Newron Pharmaceuticals, which sold the rights to Merck-Serono in 2006. In October 2011 Merck-Serono announced that they would give all rights to develop the compound back to Newron.

基本信息

CAS:202825-46-5
中文别名:马波沙星,麻保沙星;
英文别名:Safinamide Mesylate;(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide,methanesulfonic acid;(S)-2-(4-(3-fluorobenzyloxy)benzylamino)propanamide,methanesulfonate;(S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide;PNU-151774E,NW-1015;FCE-28073(R-isomer),PNU-151774E,NW-1015;(S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide;
分子式:C18H23FN2O5S
分子量:398.449
精确质量:398.131
Psa:127.1
Logp:4.0441

编号系统

MDL号:MFCD15145475

物化性质

沸点:476.7ºC at 760 mmHg
闪点:242.1ºC
蒸汽压:2.98E-09mmHg at 25°C

安全信息

海关编码:2924299090
危险标志:GHS05, GHS06, GHS09
危险性描述:H301; H318; H400
危险性防范说明:P273; P280; P301 + P310; P305 + P351 + P338
信号词:Danger

生产方法及用途

合成路线

上游原料

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图谱

1H NMR : Predict


13C NMR : Predict


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