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(3R,4S)-3-(1-乙氧乙氧基)-2-氧-4-苯基-吖丁啶羧酸叔丁基酯
tert-butyl (3R,4S)-3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate
化合物简介
(3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is used as a reagent in the synthesis of abeo-taxane derivatives that possess broad inhibitory effects against proliferation of colon cancer, melanoma, and renal cancer cell lines. (3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is also used as a reagent in the synthesis of a novel D-ring modified Docetaxel analogue which has proven to have equipotent cytotoxicity in relation to Paclitaxel towards cancer cell lines.
基本信息
CAS:201856-57-7
中文别名:(3R,4S)-1-叔丁氧基羰基-3-(2-乙氧乙氧基)-4-苯基-2-丙内酰胺;(3R,4S)-1-叔丁氧基羰基-3-(1-乙氧基乙氧基)-4-苯基-2-氮杂环丁酮;
英文别名:
分子式:C18H25NO5
分子量:335.395
精确质量:335.173
Psa:65.07
Logp:3.2106
中文别名:(3R,4S)-1-叔丁氧基羰基-3-(2-乙氧乙氧基)-4-苯基-2-丙内酰胺;(3R,4S)-1-叔丁氧基羰基-3-(1-乙氧基乙氧基)-4-苯基-2-氮杂环丁酮;
英文别名:
分子式:C18H25NO5
分子量:335.395
精确质量:335.173
Psa:65.07
Logp:3.2106
编号系统
物化性质
密度:1.16
沸点:459.6ºC at 760 mmHg
闪点:231.8ºC
折射率:1.532
蒸汽压:1.25E-08mmHg at 25°C
沸点:459.6ºC at 760 mmHg
闪点:231.8ºC
折射率:1.532
蒸汽压:1.25E-08mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
