Amiloride is a potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure. Amiloride was also tested as treatment of cystic fibrosis, but it was revealed inefficient in vivo due to its short time of action, therefore longer-acting epithelial sodium channel (ENaC) inhibitors may prove more effective, e.g. benzamil.

CAS：2016-88-8
中文别名：阿米洛利;阿米洛利盐酸盐水合物;N-脒基-3,5-二氨基-6-氯吡嗪甲酰胺盐酸盐;氨氯吡咪;
英文别名：AMIPRAMIDIN;amiloridechloride;AMipraMidine;N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate;GUANAMPRAZINE;Arumil;Amiloridhydrochlorid;HCL AMILORIDE HCL;Amiloride (hydrochloride);3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide Hydrochloride Hydrate;AMipraMizi;amiprazidine;AMIPRAMIZIDE;Amiloride HCl;Amiloride hydrochloride;N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride;AMILORIDE HCL;3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride;
分子式：C6H9Cl2N7O
分子量：266.088
精确质量：265.025
Psa：156.79
Logp：2.073

RTECS号：UQ2275500
EINECS号：217-958-2
PubChem号：24277817
MDL号：MFCD00058197

外观与性状：淡黄色固体
密度：2.11 g/cm3
沸点：628.1ºC at 760 mmHg
熔点：293-294°C
闪点：333.7ºC
储存条件：Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
蒸汽压：1.08E-15mmHg at 25°C

RTECS号：UQ2275500
安全说明：S36-S45
WGK Germany：3
危险类别码：R25
危险品运输编码：UN 2811 6.1/PG 3
海关编码：29339980
危险类别：6.1(a)
包装等级：II
危险品标志：T

用途
为较强的保钾利尿药，常和氢氯噻嗪、呋塞米合用，因不经肝代谢，肝功能损害者仍可应用。