(3S,6R,7S,12Z,15S,16E)-3,7-二-{[叔-丁基(二甲基)硅烷基]氧基}-15-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代十七碳-12,16-二烯酸 (3S,6R,7S,8S,12Z,15S,16E)-3,7-bis{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid CAS号193146-26-8分子式、结构式、MSDS、物化性质、用途-化学科研者一站式服务平台

化合物简介

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

基本信息

CAS：193146-26-8
中文别名：
英文别名：
分子式：C39H71NO6SSi2
分子量：738.22
精确质量：737.454
Psa：134.19
Logp：10.8454

编号系统

物化性质

蒸汽压：0mmHg at 25°C

安全信息

生产方法及用途

合成路线

上游原料

下游产品

图谱

1H NMR : Predict

13C NMR : Predict