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(2S)-N-[(4S)-5-{[(2,6-二甲基苯氧基)乙酰基]氨基}-4-羟基-1,6-二苯基-2-己烷基]-2-(2,4-二氧代四氢-1(2H)-嘧啶基)-3-甲基丁烷酰胺
Lopinavir Metabolite M-1
化合物简介
A major metabolite of Lopinavir .
基本信息
CAS：192725-39-6
中文别名：
英文别名：(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2,4-dionyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane;(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-de;4-Oxo-ABT-378;(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- d;
分子式：C37H46N4O6
分子量：642.784
精确质量：642.342
Psa：137.07
Logp：5.6344
中文别名：
英文别名：(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2,4-dionyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane;(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-de;4-Oxo-ABT-378;(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- d;
分子式：C37H46N4O6
分子量：642.784
精确质量：642.342
Psa：137.07
Logp：5.6344
编号系统
物化性质
折射率：1.582
安全信息
生产方法及用途
合成路线
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参考文献
Sham, Hing L; Betebenner, David A; Herrin, Thomas; Kumar, Gondi; Saldivar, Ayda; Vasavanonda, Sudthida; Molla, Akhter; Kempf, Dale J; Plattner, Jacob J; Norbeck, Daniel W Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1351 - 1353
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
