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化合物简介
Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the names Zelnorm and Zelmac for the management of irritable bowel syndrome and constipation. Approved by the FDA in 2002, it was subsequently removed from the market in 2007 due to FDA concerns about possible adverse cardiovascular effects. Before then, it was the only drug approved by the United States Food and Drug Administration to help relieve the abdominal discomfort, bloating, and constipation associated with irritable bowel syndrome. Its use was also approved to treat chronic idiopathic constipation.
基本信息
CAS:189188-57-6
中文别名:2-[(5-甲氧基-1H-吲哚-3-基)亚甲基]-N-戊基卡巴肼马来酸盐;
英文别名:Tegaserod maleate;Tegaserod Maleate;
分子式:C20H27N5O5
分子量:417.459
精确质量:417.201
Psa:168.38
Logp:3.3161
中文别名:2-[(5-甲氧基-1H-吲哚-3-基)亚甲基]-N-戊基卡巴肼马来酸盐;
英文别名:Tegaserod maleate;Tegaserod Maleate;
分子式:C20H27N5O5
分子量:417.459
精确质量:417.201
Psa:168.38
Logp:3.3161
编号系统
UNII:E5XNT3RF5A
物化性质
外观与性状:白色粉末
沸点:661.4ºC at 760 mmHg
熔点:180-183ºC
闪点:353.8ºC
蒸汽压:2.15E-18mmHg at 25°C
沸点:661.4ºC at 760 mmHg
熔点:180-183ºC
闪点:353.8ºC
蒸汽压:2.15E-18mmHg at 25°C
安全信息
海关编码:2933990090
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict

13C NMR : Predict
