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化合物简介
Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, being developed by Bristol-Myers Squibb, that is currently in phase I/II clinical trials. The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes.
基本信息
CAS：182760-06-1
中文别名：里氟康唑;4-[2-[(2R,3r)-3-(2,4-二氟苯基)-3-羟基-4-(1,2,4-噻唑)丁基]-1,3-噻唑]苯甲腈;
英文别名：RCZ;4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile;
分子式：C22H17F2N5OS
分子量：437.465
精确质量：437.112
Psa：115.86
Logp：4.24298
中文别名：里氟康唑;4-[2-[(2R,3r)-3-(2,4-二氟苯基)-3-羟基-4-(1,2,4-噻唑)丁基]-1,3-噻唑]苯甲腈;
英文别名：RCZ;4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile;
分子式：C22H17F2N5OS
分子量：437.465
精确质量：437.112
Psa：115.86
Logp：4.24298
编号系统
UNII：95YH599JWV
物化性质
密度：1.38g/cm3
沸点：674.9ºC at 760 mmHg
闪点：362ºC
折射率：1.665
蒸汽压：3.89E-19mmHg at 25°C
沸点：674.9ºC at 760 mmHg
闪点：362ºC
折射率：1.665
蒸汽压：3.89E-19mmHg at 25°C
安全信息
危险性防范说明：P280; P305 + P351 + P338; P337 + P313
信号词：Warning
危险标志：GHS07
危险性描述：H315; H319; H335
信号词：Warning
危险标志：GHS07
危险性描述：H315; H319; H335
生产方法及用途
合成路线
-
参考文献
Pesti, Jaan; Chen, Chien-Kuang; Spangler, Lori; DelMonte, Albert J.; Benoit, Serge; Berglund, Derek; Xbien, Derek; Brodfuehrer, Paul; Chan, Yeung; Corbett, Elisabeth; Costello, Carrie; DeMena, Paul; Discordia, Robert P.; Doubleday, Wendel; Gao, Zhinong; Gingras, Stephane; Grosso, John; Haas, Oscar; Kacsur, David; Lai, Chiajen; Leung, Simon; Miller, Melanie; Muslehiddinoglu, Jale; Nguyen, Nina; Qiu, Jun; Olzog, Martina; Reiff, Emily; Thoraval, Dominique; Totleben, Michael; Vanyo, Dale; Vemishetti, Purushotham; Wasylak, John; Wei, Chenkou Organic Process Research and Development, 2009 , vol. 13, # 4 p. 716 - 728
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
