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化合物简介
Prucalopride (brand name Resolor, developed by Johnson & Johnson and licensed to Movetis) is a drug acting as a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalizing bowel movements. Prucalopride was approved for use in Europe in 2009, in Canada (named Resotran) on December 7, 2011 and in Israel in 2014 but it has not been approved by the Food and Drug Administration for use in the United States. The drug has also been tested for the treatment of chronic intestinal pseudo-obstruction.
基本信息
CAS：179474-81-8
中文别名：7-苯并呋喃甲酰胺,4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基];普卡比利;普卡必利;
英文别名：Resolor;4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide;Unii-0A09iuw5tp;
分子式：C18H26ClN3O3
分子量：367.87
精确质量：367.166
Psa：76.82
Logp：2.9978
中文别名：7-苯并呋喃甲酰胺,4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基];普卡比利;普卡必利;
英文别名：Resolor;4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide;Unii-0A09iuw5tp;
分子式：C18H26ClN3O3
分子量：367.87
精确质量：367.166
Psa：76.82
Logp：2.9978
编号系统
UNII：0A09IUW5TP
物化性质
密度：1.28g/cm3
沸点：481.4ºC at 760mmHg
闪点：244.9ºC
折射率：1.599
蒸汽压：2E-09mmHg at 25°C
沸点：481.4ºC at 760mmHg
闪点：244.9ºC
折射率：1.599
蒸汽压：2E-09mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
Predict 1H proton NMR
