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  • 7-羟基帽柱碱

    7-Hydroxymitragynine

化合物简介

7-Hydroxymitragynine is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as Kratom. It is orally active and has analgesic effects.]],; 7-Hydroxymitragynine is a partial agonist at the μ-opioid receptor with a potency, calculated using pD (2) values, that is 30-fold higher than that of mitragynine and 17-fold higher than that of morphine, respectively. As a G protein biased ligand at this receptor it causes significantly less side effects than morphine, like constipation, development of tolerance and withdrawal syndrome upon abstinence. The O-acetyl ester (Acetoxy), 7-acetoxymitragynine has also been reported and found to be an active μ-opioid agonist.

基本信息

CAS:174418-82-7
中文别名:7-羟基帽柱木碱;
英文别名:7α-Hydroxy-7H-mitragynine;9-Methoxycorynantheidine hydroxyindolenine;7-Hydroxy Mitragynine;Mitragynine hydroxyindolenine;Methyl (E)-2-[(2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate;
分子式:C23H30N2O5
分子量:414.495
精确质量:414.215
Psa:80.59
Logp:2.1661

编号系统

UNII:2T3TWA75R0

物化性质

储存条件:-20°C

安全信息

生产方法及用途

合成路线

上游原料

下游产品

图谱

1H NMR : Predict


13C NMR : Predict


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