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化合物简介

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.\nCelecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon

基本信息

CAS:169590-42-5
中文别名:塞内昔布;噻利考西;
英文别名:N-[4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1yl]phenylsulfonyl]benzensulfonamide;YM 177;CELEBREX;Celecoxib;4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide;4-(5-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide;celexicob;Celebrex,Celebra;Celocoxib;Celecox;1-(4-sulphamoylphenyl)-3-trifluoromethyl-5-(p-tolyl)-pyrazole;4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene sulfonamide;Celebra;
分子式:C17H14F3N3O2S
分子量:381.372
精确质量:381.076
Psa:86.36
Logp:5.295

编号系统

MDL号:MFCD00941298

物化性质

外观与性状:白色粉末
密度:1.43g/cm3
沸点:529ºC at 760 mmHg
熔点:157-159ºC
闪点:273.7ºC
折射率:1.605
蒸汽压:2.81E-11mmHg at 25°C

安全信息

安全说明:S22-S24/25-S28-S37/39
危险类别码:R20/21/22
海关编码:2935009090
危险品运输编码:UN 2811

生产方法及用途

用途
用于治疗关节炎,具有抗炎镇痛、缓解骨关节炎和类风湿关节炎症状和体征的作用。

合成路线

上游原料

下游产品

图谱

Predict 1H proton NMR


13C NMR : Predict


1H NMR : Predict


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