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(6R,7R)-7-[[2-[2-(氨基甲基)苯基]乙酰]氨基]-3-[[1-(羧甲基)四唑-5-基]硫甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
(2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol
化合物简介
Zosuquidar is an experimental antineoplastic drug currently under development. It has completed Phase 3 clinical trials in the United States. It inhibits P-glycoproteins. Other drugs with this mechanism include tariquidar and laniquidar. P-glycoproteins are trans-membrane proteins that pump foreign substances out of cells in an ATP dependent fashion. Cancers overexpressing P-glycoproteins are able to pump out therapeutic molecules before they are able to reach their target, effectively making the cancer multi-drug resistant. Zosuquidar inhibits P-glycoproteins, inhibiting the efflux pump and restoring sensitivity to chemotherapeutic agents.
基本信息
CAS：167354-41-8
中文别名：(2R)-1-{4-[(1AR,6R,10BS)-1,1-二氟-1,1A,6,10B-四氢二苯并[A,E]环丙并[C]环庚烯-6-基]哌嗪-1-基}-3-(喹啉-5-基氧基)丙-2-醇;唑喹达;ZOSUQUIDAR;
英文别名：Zosuquidar;Unii-ab5K82X98y;Zosuquidar [inn];
分子式：C32H31F2N3O2
分子量：527.604
精确质量：527.238
Psa：48.83
Logp：5.0872
中文别名：(2R)-1-{4-[(1AR,6R,10BS)-1,1-二氟-1,1A,6,10B-四氢二苯并[A,E]环丙并[C]环庚烯-6-基]哌嗪-1-基}-3-(喹啉-5-基氧基)丙-2-醇;唑喹达;ZOSUQUIDAR;
英文别名：Zosuquidar;Unii-ab5K82X98y;Zosuquidar [inn];
分子式：C32H31F2N3O2
分子量：527.604
精确质量：527.238
Psa：48.83
Logp：5.0872
编号系统
UNII：AB5K82X98Y
物化性质
密度：1.36g/cm3
沸点：690.5ºC at 760mmHg
闪点：371.4ºC
折射率：1.691
沸点：690.5ºC at 760mmHg
闪点：371.4ºC
折射率：1.691
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
