FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).

CAS：162359-56-0
中文别名：芬戈莫德盐酸盐;2-氨基-2-[2-(4-正辛基苯基)乙基]丙烷-1,3-二醇盐酸盐;芬戈莫德(FTY-720);盐酸曲吡那敏;2-氨基-2-[2-(4-辛烷基苯基)乙基]-1,3-丙二醇盐酸盐;
英文别名：FTY720 Hydrochloride;Fingolimod HCl/FTY720;Fingolimod HCl;Fingolimod Hydrochloride;2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride;2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride;2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride Fingolimod hydrochloride;
分子式：C19H34ClNO2
分子量：343.932
精确质量：343.228
Psa：66.48
Logp：4.7066

MDL号：MFCD00939512

外观与性状：白色固体
密度：1.016g/cm3
沸点：479.5ºC at 760 mmHg
熔点：102-107ºC
闪点：243.8ºC
折射率：1.531
蒸汽压：5.28E-10mmHg at 25°C

海关编码：2922199090
危险性防范说明：P261; P273; P305 + P351 + P338
危险性描述：H315; H319; H335; H412
危险标志：GHS07
信号词：Warning