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化合物简介
Perifosine (also KRX-0401) is a drug candidate being developed for a variety of cancer indications. It is an alkyl-phospholipid structurally related to miltefosine. It acts as an Akt inhibitor and a PI3K inhibitor. It was being developed by Keryx Biopharmaceuticals who have licensed it from Æterna Zentaris Inc.
基本信息
CAS：157716-52-4
中文别名：(1,1-二甲基哌啶-1--4-基)十八烷基磷酸酯;
英文别名：Perifosine (KRX-0401);(1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate;Piperidinium (4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl;1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate;
分子式：C25H52NO4P
分子量：461.658
精确质量：461.363
Psa：68.4
Logp：8.0173
中文别名：(1,1-二甲基哌啶-1--4-基)十八烷基磷酸酯;
英文别名：Perifosine (KRX-0401);(1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate;Piperidinium (4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl;1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate;
分子式：C25H52NO4P
分子量：461.658
精确质量：461.363
Psa：68.4
Logp：8.0173
编号系统
MDL号：MFCD00927554
物化性质
熔点：271-272°(dec)
外观性状：whitetobeige
储存条件：?20°C
水溶解性：H2O:soluble10mg/mL,clear
外观性状：whitetobeige
储存条件：?20°C
水溶解性：H2O:soluble10mg/mL,clear
安全信息
海关编码：2933399090