Safingol is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin.

CAS：15639-50-6
中文别名：L-苏式-二氢神经鞘氨醇;
英文别名：L-THREO-DIHYDROSPHINGOSINE;L-threo-dihydrosphingosine;L-threo sphinganine,2S,3S) L-threo-2-amino-1,3-octadecanediol;
分子式：C18H39NO2
分子量：301.508
精确质量：301.298
Psa：66.48
Logp：4.8485

MDL号：MFCD00792847

密度：0.927 g/cm3
沸点：446.2ºC at 760 mmHg
闪点：223.7ºC
折射率：1.477
储存条件：-20ºC
蒸汽压：7.75E-10mmHg at 25°C

海关编码：2922199090