PyAOP ((7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate) is a coupling reagent used in solid phase peptide synthesis. It is a derivative of the HOAt family of coupling reagents. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen.

CAS：156311-83-0
中文别名：六氟磷酸(7-氮杂苯并三唑-1-氧基)三吡咯烷磷;(3H-1,2,3-三唑并[4,5-b]吡啶-3-氧基)三-1-吡咯烷基六氟磷酸盐;(3H-1,2,3-三唑并[4,5-b]吡啶-3-氧基)三-1-吡咯烷基鏻六氟磷酸盐;
英文别名：tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphanium,hexafluorophosphate;
分子式：C17H27F6N7OP2
分子量：521.381
精确质量：521.166
Psa：89.73
Logp：5.416

MDL号：MFCD03703417

熔点：163-168°C(lit.)

安全说明：S26-S36
WGK Germany：3
危险类别码：R36/37/38
危险品标志：Xi