化学科研者一站式服务平台
-
O-(7-氮杂苯并三唑-1-基)-N,N,N',N'-四甲基脲六氟磷酸盐
2-(7-Aza-1H-Benzotriazole-1-yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate
化合物简介
HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds. Generally DMF is used as solvent, although other polar organic solvents can also be used.
基本信息
CAS：148893-10-1
中文别名：HATU;2-(7-氮杂苯并三氮唑)-四甲基脲六氟磷酸盐;
英文别名：O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate;[dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium,hexafluorophosphate;2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;O-(7-Azabenzotriazol-1-yl)-N,N,N\',N\'-tetramethyluronium hexafluorophosphate;2-(7-Aza-1H-Benzotriazo;N,N,N\',N\'-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate;
分子式：C10H15F6N6OP
分子量：380.23
精确质量：380.095
Psa：72.67
Logp：2.827
中文别名：HATU;2-(7-氮杂苯并三氮唑)-四甲基脲六氟磷酸盐;
英文别名：O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate;[dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium,hexafluorophosphate;2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;O-(7-Azabenzotriazol-1-yl)-N,N,N\',N\'-tetramethyluronium hexafluorophosphate;2-(7-Aza-1H-Benzotriazo;N,N,N\',N\'-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate;
分子式：C10H15F6N6OP
分子量：380.23
精确质量：380.095
Psa：72.67
Logp：2.827
编号系统
MDL号：MFCD00274639
物化性质
外观与性状：白色晶体粉末
沸点：176ºC at 760mmHg
熔点：183-188°C (dec.)
储存条件：2-8ºC
沸点：176ºC at 760mmHg
熔点：183-188°C (dec.)
储存条件：2-8ºC
安全信息
安全说明：S26-S37/39-S36/37
WGK Germany：3
危险类别码：R36/37/38
危险品标志：Xi
WGK Germany：3
危险类别码：R36/37/38
危险品标志：Xi
生产方法及用途
合成路线
上游原料
下游产品
图谱
Predict 1H proton NMR
13C NMR : Predict
1H NMR : Predict
