Talsaclidine (WAL-2014) is a non-selective muscarinic acetylcholine receptor agonist which acts as a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes. It was under development for the treatment of Alzheimer's disease but showed only modest or poor efficacy in rhesus monkeys and humans, respectively, perhaps due to an array of dose-limiting side effects including increased heart rate and blood pressure, increased salivation, urinary frequency and burning upon urination, increased lacrimation and nasal secretion, abnormal accommodation, heartburn, upset stomach as well as cramps, nausea, vomiting and diarrhea, excessive sweating and palpitations.

CAS：147025-53-4
中文别名：
英文别名：WAL 2014;Talsaclidine;
分子式：C10H15NO
分子量：165.232
精确质量：165.115
Psa：12.47
Logp：0.6683

UNII：1O8VSL798T

密度：1.06g/cm3
沸点：251.1ºC at 760mmHg
闪点：73.3ºC
折射率：1.525
储存条件：-20ºC
蒸汽压：0.0208mmHg at 25°C

安全说明：S26
危险类别码：R41
危险品标志：Xi