Alvocidib (INN; also known as Flavopiridol or HMR-1275) is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development for the treatment of acute myeloid leukemia, by Tolero Pharmaceuticals, Inc. It has been studied also for the treatment of arthritis and atherosclerotic plaque formation The target of Flavopiridol is the positive transcription elongation factor P-TEFb. Treatment of cells with Flavopiridol leads to inhibition of P-TEFb and the loss of mRNA production.

CAS：146426-40-6
中文别名：磷酸氟达拉滨;FLAVOPIRIDOL;2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃;2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃-4-酮;HMR-1275;
英文别名：Flavopirodol;Alvocidib;Alvocidib,Free Base;
分子式：C21H20ClNO5
分子量：401.84
精确质量：401.103
Psa：94.14
Logp：3.2425

MDL号：MFCD20501884

外观与性状：黄色粉末
密度：1.448 g/cm3
沸点：603.6ºC at 760 mmHg
闪点：318.8ºC
折射率：1.708