Ro5-4864 (4'-chlorodiazepam) is a drug which is a benzodiazepine derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a potent ligand for the \"peripheral benzodiazepine receptor\", later renamed to mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity. In vitro studies and rodent models also suggest the possibility of analgesic, antidepressant, cardioprotective, and anti-cancer effects.[non-primary source needed]

CAS：14439-61-3
中文别名：
英文别名：Chlorodiazepam;4\'-Chlorodiazepam;7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one;Ro-5-4864;
分子式：C16H12Cl2N2O
分子量：319.185
精确质量：318.033
Psa：32.67
Logp：3.3078

UNII：2QW0IK1742

密度：1.35g/cm3
沸点：517.1ºC at 760mmHg
熔点：160-163ºC
闪点：266.6ºC
折射率：1.647
蒸汽压：8.43E-11mmHg at 25°C

危险类别码：R22
海关编码：2933990090
危险品运输编码：UN 2811
危险类别：6.1(b)
包装等级：III
危险品标志：Xn