Diarylpropionitrile (DPN), also known as 2,3-bis(p-hydroxyphenyl)propionitrile (2,3-BHPPN), is a synthetic, non-steroidal, and highly selective agonist of ERβ (IC50 = 15 nM) that is used widely in scientific research to study the function of this receptor. It is 70-fold more selective for ERβ over ERα, and has 100-fold lower affinity for GPER (GPR30) relative to estradiol. DPN produces antidepressant- and anxiolytic-like effects in animals via activation of the endogenous oxytocin system.

CAS：1428-67-7
中文别名：
英文别名：2,3-bis(4-hydroxyphenyl)propanenitrile;2,3-Bis(4-hydroxyphenyl)propionitrile;DPN Diarylpropionitrile SC-4473;
分子式：C15H13NO2
分子量：239.269
精确质量：239.095
Psa：64.25
Logp：2.94768

外观与性状：灰白色固体
密度：1.256 g/cm3
沸点：449.4ºC at 760 mmHg
闪点：225.6ºC
折射率：1.639
蒸汽压：1.08E-08mmHg at 25°C

信号词：Warning
危险性防范说明：P273; P305 + P351 + P338
危险性描述：H319; H400
危险标志：GHS07, GHS09