Nefopam (brand names: Acupan, Silentan, Nefadol and Ajan) is a centrally-acting non-opioid analgesic drug of the benzoxazocine chemical class which was developed by Riker Laboratories in the 1960s. It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic drugs. Animal studies have shown that nefopam has a potentiating (analgesic-sparing) effect on morphine and other opioids by broadening the antinociceptive action of the opioid and possibly other mechanisms, generally lowering the dose requirements of both when they are used concomitantly.

CAS：13669-70-0
中文别名：
英文别名：5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride;Nefopam;5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine;
分子式：C17H19NO
分子量：253.339
精确质量：253.147
Psa：12.47
Logp：3.1759

UNII：4UP8060B7J

密度：1.064g/cm3
沸点：369.5ºC at 760 mmHg
闪点：109ºC
折射率：1.563
蒸汽压：1.18E-05mmHg at 25°C

海关编码：2933990090

生产方法
由2-苯酰苯酸与亚硫酰氯反应,然后再与2-甲氨基乙醇反应制取2-[[N-(2-羟乙基)-N-甲基]胺]甲基二苯基甲醇,将其与对甲苯磺酸和苯一起加热蒸苯,生成的油状物碱化即得奈福泮盐基。 用于术后止痛、癌症痛、急性外伤痛的治疗,亦适用于急性胃炎、胆道蛔虫症、输尿管结石等内脏平滑肌绞痛
用途
用于术后止痛、癌症痛、急性外伤痛的治疗,亦适用于急性胃炎、胆道蛔虫症、输尿管结石等内脏平滑肌绞痛