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(S)-N-(1-氮杂双环环[2.2.2]-3-辛基)-5,6,7,8-四氢-1-萘羧酰胺
N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide
化合物简介
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide is an intermediate in the synthesis of Palonosteron, an serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
基本信息
CAS：135729-78-1
中文别名：盐酸帕洛诺司琼中间体;帕洛诺司琼中间体 3;(S)-N-(1-氮杂双环[2.2.2]辛-3-基)-5,6,7,8-四氢-1-萘甲酰胺;
英文别名：N-((S)-1-azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide;N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide;N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxide;1-Naphthalenecarboxamide,N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro;N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxamide;(S)-N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENECARBOXAMIDE;
分子式：C18H24N2O
分子量：284.396
精确质量：284.189
Psa：32.34
Logp：2.7182
中文别名：盐酸帕洛诺司琼中间体;帕洛诺司琼中间体 3;(S)-N-(1-氮杂双环[2.2.2]辛-3-基)-5,6,7,8-四氢-1-萘甲酰胺;
英文别名：N-((S)-1-azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide;N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide;N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxide;1-Naphthalenecarboxamide,N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro;N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxamide;(S)-N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENECARBOXAMIDE;
分子式：C18H24N2O
分子量：284.396
精确质量：284.189
Psa：32.34
Logp：2.7182
编号系统
物化性质
密度：1.17
沸点：439.2ºC at 760 mmHg
折射率：1.609
蒸汽压：6.48E-08mmHg at 25°C
沸点：439.2ºC at 760 mmHg
折射率：1.609
蒸汽压：6.48E-08mmHg at 25°C
安全信息
海关编码：2933990090
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
