A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.

CAS：134036-52-5
中文别名：A-氰基-(3,4-二羟基)-N-苄基肉桂胺;
英文别名：
分子式：C17H14N2O3
分子量：294.305
精确质量：294.1
Psa：93.35
Logp：2.71208

外观与性状：黄色固体
密度：1.337g/cm3
沸点：615.2ºC at 760mmHg
熔点：215ºC
闪点：325.9ºC
储存条件：-20ºC

安全说明：S26; S36
危险类别码：R36/37/38
危险品标志：Xi